A very basic rule.
Let’s look at this sentence.
Father Andres Simpkinson, will tell us about his missionary work.
No! What’s that comma doing there?
Here’s another sentence.
The sisters, neither of whom liked their eldest sister, drained their mother’s estate while fighting her reasonable and legal demands for the yearly accounting.
This is okay, since the pair of commas enclose a parenthetical phrase; “pulled” out, you have a working sentence. But you’ve got to have a pair of commas, or it doesn’t work.